Aiming at the requirements of rich interfaces, enhanced floating-point calculation and high reliability for Unmanned Aerial Vehicle(UAV) flight control computer, a kind of UAV flight control computer based on dual Digital Signal Processor(DSP) TMS320F28335(abbr. DSP28335) is proposed. The one DSP is used for comprehensive treatment of navigation and sensor information, and the other is dedicated to control law calculating and airborne mission management. Powerful computing and information processing capacity, rich on-chip resources and high reliability for its simplified circuit and CPU derating use are implemented with the dual-core design. The proposed computer has been successfully applied to the collecting and processing of navigation information and gyroscope drift compensation of Kalman filtering algorithm in a real-time Micro Electro Mechanical Systems(MEMS).