Aiming for the disadvantages of traditional hardware simulation, a new method is proposed, which introduces EDA technology into the SCM I2C(Inter-Integrated Circuit) bus communication design. Taking AT24C02 device as an example, the method using virtual technology to design hardware and software of Proteus I2C bus communication is described in detail, which enables concurrent co-development of hardware and software for the SCM system. The proposed method can effectively save hardware resources, and improve the development efficiency. Simulation results agree well with the theoretical analysis, which verifies the correctness and accuracy of Proteus virtual simulation.