Penetration process generates mechanical vibrations, and some frequencies of these mechanical vibrations are close to the resonance frequency of the piezoresistive sensor, which will cause the elements out of control at resonance and eventually cause gage breakdown. A signal conditioning interface circuit is introduced toward the application of PR sensor in penetration circumstance. The interface circuit realizes signal process properly, and zero-output and zero-shift are adjusted in real time accordingly, which guarantees the signal integrity and real-time processing. Circuit modeling simulation and semi-physical simulation demonstrate the zero-shift problem can be solved properly by this circuit.