In order to overcome the interference of the antenna, the Genetic Algorithm(GA) is used to optimize the layout of the antenna to reduce the coupling between antennas. By using a new objective function, combining with the Uniform geometrical Theory of Diffraction(UTD), layout optimization is performed on the monopole antennas both on the cylinder and on the surface of Unmanned Aerial Vehicle(UAV). The results of location optimization are proved by Feko simulation, and the S parameter values at the best position show that the coupling between antennas becomes smaller after the placement optimization, which also indirectly validates the correctness of the method. This method can be applied to predict and evaluate the coupling degree of the airborne antenna on time and has practical application value.