The development of Complementary Metal Oxide Semiconductor(CMOS) integrated circuit and the key technologies of nanometer scale CMOS integrated circuit are introduced. Based on this, the radiation effects and the current status of radiation hardening for nano scale CMOS integrated circuit are studied. The research shows that the nano scale FDSOICMOS integrated circuit bears a better radiation hardening ability than the same technology generation of bulk silicon CMOS integrated circuit, and it is especially suitable for the application of space technology.