The new-energy vehicles are mainly powered by electricity. Its power cables transmit the transient signals of high voltage and power. In addition, the antenna effect of the cable makes the cable become the dominant emission source of electromagnetic interference in electric vehicles. The power cable also exerts the crosstalk on the surrounding signal cables. This research analyzes the source of electromagnetic interference in power cables. Then the simplified model of power cable and adjacent cable is established using FEKO tool. The effect of these factors on restraining crosstalk is compared and analyzed by changing the settings of the cable shield layer and the metal groove in the simulation model. Finally, based on the simulation results, it is concluded that reducing the impedance of the cable shielding layer and increasing the use of the metal groove are helpful to minimize the cable’s crosstalk effects.