The inaccurate control of the valve positioner in industrial process control would cause the valve position to reciprocate and fluctuate. To solve this problem, a circuit board of pneumatic intelligent valve positioning control is designed. The hardware design is based on micro-processing STC12C5A6052 and outputs bipolar PWM(Pulse Width Modulation) pulse to drive the piezoelectric valve. The peripheral circuit includes power conversion circuit, I/V conversion circuit, A/D sampling circuit, button and liquid crystal display circuit, etc. Because the valve control and execution process is nonlinear time-varying, it is difficult to establish an accurate mathematical model. Therefore, a fuzzy PID(Proportion Integration Differentiation) control algorithm is utilized instead of the conventional PlD control in the control system. By improving the designs in software and hardware, the valve position fluctuation can be effectively avoided. The stable transition time is only 1.2 s and the system has no overshoot. In Matlab, the transfer function of the mathematical model and the measured data of the valve position are simulated by various mechanisms of the valve. Through waveform comparison, the control circuit board of designed valve positioner can make the valve control more stable, fast and accurate.