A high performance fully differential folded-cascode amplifier is designed. On the one hand, in order to improve the amplifier’s precision and dynamic performance, the chopper and class-AB push-pull technique are applied in the circuit; on the other hand, to further improve the voltage margin and robustness in the circuit, the self-cascode current source is applied in the amplifier. The circuit is realized based on the CSMC 0.35 μm CMOS technique, and the layout area is about 640 μm×280 μm. The simulation results show: at a power supply of 5 V and the chopping frequency of 156.25 kHz, the equivalent input noise is 1.11 nV/Hz1/2, the offset voltage is 61.5 μV and the power consumption is 1.22 mW.