With the actually used frequency band going higher and higher in wireless communications, the influence of phase noise induced by imperfect carrier on Multi-Input Multi-Output Orthogonal Frequency Division Multiplexing(MIMO-OFDM) systems are becoming increasingly acute. This results in not only the destruction of the orthogonality of OFDM system carriers, but also the multiple-antenna precoding performance degradation. The influence of phase noise on MIMO-OFDM systems are composed of Common Phase Error(CPE) and Inter-Carrier Interference(ICI). In this paper, it is first analyzed that how CPE influences the performance of a MIMO-OFDM system, after which a series of novel CPE estimation algorithms are proposed based on frequency domain orthogonal pilot design; finally the validity and reliability of the algorithms are verified by system link simulation under various wireless transmission scenarios.