Estimation of five common substances in nerve cells by terahertz spectroscopy
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    Abstract:

    The spectra of five substances commonly in nerve cells including, L-glutamic acid, Gamma Amino Butyric Acid(GABA), creatine, dopamine hydrochloride and myo-inositol are investigated by Terahertz Time-Domain Spectroscopy(THz-TDS). The experimental results show that the five substances have obvious and unique absorption spectra in terahertz region. For the same material, absorbance coefficient of different concentrations agrees with Lambert-Beer Law. In addition, the spectra of five substances are simulated by using CASTEP software package. The results show that the absorption peaks of terahertz spectrum are mainly due to the vibration of molecular groups. Furthermore, the spectra of 1:1:1:1 mixture of GABA, creatine, L-glutamic acid, myo-inositol are tested. By using the Least Square Method(LSM), the proportion and percentage of each substance are deduced exactly. The results show that the accuracy of substance content prediction is more than 94% when the four substances are mixed, which is of great significance for the early detection of cancer tissue.

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罗 洁,寇天一,施辰君,吴 旭.神经细胞中五种常见物质的太赫兹波谱的推定[J]. Journal of Terahertz Science and Electronic Information Technology ,2019,17(1):35~39

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History
  • Received:May 30,2018
  • Revised:July 15,2018
  • Adopted:
  • Online: March 27,2019
  • Published: