The communication countermeasure simulation based on Multi-Agent is studied. According to the battlefield environment, actual needs and the synergy between Multi-Agent, the attributes, parameters and behaviors of Multi-Agents are analyzed and defined. According to the design rules of Observe-Orient-Decide-Act(OODA), a four-Quadrant Attack(QA) strategy for maximizing the individual value of the agent is proposed to achieve the autonomous attack of agents. The simulation is implemented by Repast Simphony modeling software. The effect is comprehensively observed through 2D model simulation and the effectiveness of the algorithm is backtracked. The proportion that can maximize the effectiveness of Red Attacker Agent(RAA) attacks can be tested according to the number of Blue Communication Agent(BCA) attacks. Practical application testing shows that this model has high attack rate, high realization value, which provides a new idea for the simulation of communication antagonism.